个人简介
2006年加入华东师范大学至今。
2008-2009 牛津大学访问学者‚
2005.3-2006.9 香港浸会大学交流学生、博后
2001-2006 武汉大学博士毕业
1997-2001 湖北师范学院本科毕业
个人简介
研究领域
1. 不对称合成、多组分反应：主要包括新型多组分反应的发现和不对称催化 及其在创新药物发现中的应用研究。
2. 表面功能化纳米材料：主要包括基于功能化纳米材料的表面化学设计、修饰及其在有机合成化学催化和药物载体中的应用研究。
3. 新药注册申报：化学原料药研发、注册申报的Q&D方案设计及相关法规
研究领域
专业：
研究方向：
研究领域和兴趣：
近期论文
Shunyin Liu, Wenfeng Yao, Yuan Liu, Qinghua Wei, Jianghui Chen, Xiang Wu, Fei Xia*, Wenhao Hu*. • A Rh(II)-Catalyzed Multicomponent Reaction by Trapping an α-Amino Enol Intermediate in a Traditional Two-component Reaction Pathway. Sci. Adv. 2017, 3, DOI: 10.1126/scieadv.1602467.
Xiaochu Ma, Jun Jiang, Siying Lv, Wenfeng Yao, Yang Yang, Shunying Liu*, Fei Xia and Wenhao Hu*, A YlideTransformation of Rh(I) Carbene: Enantioselective Three-component Reaction via Trapping of Rh(I) Associated Ammonium Ylides by β-Nitroacrylates, Angew. Chem. Int. Ed. 53(48), 13136-13139, 2014.
Mingfeng Li, Xin Guo, Weifeng Jin, Qing Zheng, Shunying Liu* and Wenhao Hu.* Enantioselective Three-component Reaction of Diazoacetates with Indoles and Enals by Iridium/Iminium Co-catalysis. Chem. Commun., 52, 2736-2739, 2016.
Lin Qiu, Xin Guo, Yu Qian, Changcheng Jing, Chaoqun Ma, Shunying Liu,* and Wenhao Hu. * Enantioselective oxidative functionalization of the Csp3–H bond adjacent to a nitrogen atom for rapid access to b-hydroxyl-a-amino acid derivatives Chem. Commun., 52, 52(79), 11831-11833, 2016,
Lin Qiu,Xin Guo,Chaoqun Ma,Huang Qiu,Shunying Liu,*Liping Yanga and Wenhao Hu*. Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions, Chem. Commun., 50, 2196-2198, 2014.
Jiang Jun, Ma Xiaochu, Ji Changge, Guo Zhengqiu, Shi Taodao, Liu Shunying*, Hu Wenhao*. Ruthenium(II)/Chiral Brønsted Acid Co-Catalyzed Enantioselective Four-Component Reaction/Cascade Aza-Michael Addition for Efficient Construction of 1,3,4-Tetrasubstituted Tetrahydroisoquinolines, Eur. Chem. J. 20(6), 1505-1509, 2014.
Bo Jiang, Li-Jun Chen, Lin Xu, Shun-Ying Liu* and Hai-Bo Yang*. A series of new star-shaped or branched platinum–acetylide derivatives: synthesis, characterization, and their aggregation behavior, Chem. Commun., 49, 6977-6979, 2013.
Suzheng Dong, Yubing Lei,Shikun Jia,Lixin Gao,Jia Li, Tong Zhu, Shunying Liu, * Wenhao Hu.* Discovery of Core-structurally Novel PTP1B Inhibitors with Specific Selectivity Containing Oxindole-fused Spirotetrahydrofurochroman by One-pot Reaction, Bioorg. Med. Chem. Lett.http://dx.doi.org/10.1016/j.bmcl.2016.11.055, 2016.
Lin Qiu, Dongwei Wang, Yubing Lei, LixinGao, Shunying Liu,* Jia Li and Wenhao Hu.* Diastereoselective Three-component Cascade Reaction to Construct Novel Oxindole-Fused Spirotetrahydrofuro-Chroman Scaffolds for Drug Discovery. Eur. J. Org. Chem. 2671-2680, 2016.
Min Tang, Yong Wu, Yuan Liu, Maoqiang Cai, Fei Xia, Shunying Liu,* and Wenhao Hu.* One-pot Enantioselective Multi-component Cascade Reactions for Synthesis of Chiral Functionalized Hydro-epoxyisochromenes: A Rapid Access to Molecular Complexity. Acta Chim. Sin. 74(1), 54-60, 2016. (cover paper)
Shi-Kun Jia, Yu-Bing Lei, Long-Long Song, Shun-Ying Liu *, Wen-Hao Hu*, Enantioselective trapping of oxonium ylide intermediates by N-benzhydryl-a-imino ester: Synthesis of b-tetrasubstituted a-amino acids, Chin. Chem. Lett., http://dx.doi.org/10.1016/j.cclet.2016.06.053, 2016.
Lin Qiu, Lixin Gao, Jixing Tang, Dongwei Wang, Xin Guo, Shunying Liu,*, Liping Yang, Jia Li, and Wenhao Hu*, Regio- and Diastereoselective Construction of αSulfonylimines, J. Org. Chem. 79, 4142−4147, 2014.
Zhongshi Liang, Xingui Li, Yegui Xie and Shunying Liu.* ‘Smart’ gold nanoshells for combined cancer chemotherapy and hyperthermia, Biomed. Mater. 9, 025012-025022, 2014.
Lin Qiu, Dongwei Wang, Fengping Lv, Xin Guo, Wenhao Hu, Liping Yang, Shunying Liu.* Three-component reactions based on trapping ammonium ylides with N-sulfonyl aldimines via cooperative catalysis of squaramides and Rh2(OAc)4, Tetrahedron, 70 (71), 1471-1477, 2014.
近期论文
