Khalid, Syma

个人简介

Syma graduated with a first class degree in Chemistry from the University of Warwick in 2000. She remained at Warwick to read for a PhD under the supervision of Professor P Mark Rodger. After obtaining her PhD in 2003, she moved to the University of Oxford as a postdoc in Professor Mark Sansom’s lab, to study the structure-function relationship of bacterial membrane proteins. In 2007, she was appointed as RCUK fellow in Chemistry at the University of Southampton, in 2010 was appointed to full lectureship. In 2016 she was promoted to full professor She has ~15 years of experience in the development and application of molecular dynamics simulations to the study of biological molecules. Her research interests are centred around the dynamics of biomolecules in and around biological membranes. Her formal training as a chemist combined with her interest in the biological relevance of the systems she studies enables her to adopt a truly multi-disciplinary approach; collaborators include Bert van den Berg (Newcastle), Ben Luisi (Cambridge) and Peter Bond (A*STAR, Singapore). Syma’s international reputation is reflected in the invitations she receives to speak at national and international meetings each year. Syma has authored over 40 peer-reviewed papers and 4 book chapters and is on the editorial board of Scientific Reports. She serves on the management group that leads CCPBiosim. In addition, she is a local section committee member of the RSC, and also serves on the management committee of the British Biophysical Society.

个人简介

研究领域

My research involves the application of computational techniques to the study of large biological molecules and systems including bacterial outer membrane proteins and nucleic acids. A key area of research involves capturing the biological complexity of bacterial membranes in our simulations, with a particular focus on the outer membranes of Gram-negative bacteria. In this context are developing computational models and tools to link biomolecular simulations and systems biology. We are also interested in applying the knowledge gained from studying biological systems to aid the design of synthetic systems for applications in bionanotechnology. We have strong links with experimental groups in biophysics, biochemistry, chemical biology and structural biology.

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近期论文

Molecular dynamics simulations of phosphatidylcholine membranes: a comparative force field study - Piggot, Thomas J., Piñeiro, Ángel and Khalid, Syma Published:2012Publication:Journal of Chemical Theory and ComputationVolume:8, (11)Page Range:4593-4609doi:10.1021/ct3003157 Single-stranded DNA within nanopores: conformational dynamics and implications for sequencing; a molecular dynamics simulation study - Guy, Andrew T., Piggot, Thomas J. and Khalid, Syma Published:2012Publication:Biophysical JournalVolume:103, (5)Page Range:1028-1036doi:10.1016/j.bpj.2012.08.012PMID:23009852 Electroporation of the E. coli and S. Aureus membranes: molecular dynamics simulations of complex bacterial membranes - Piggot, Thomas J., Holdbrook, Daniel A. and Khalid, Syma Published:2011Publication:The Journal of Physical Chemistry BVolume:115, (45)Page Range:13381-13388doi:10.1021/jp207013vPMID:21970408 Outer membrane protein G: engineering a quiet pore for biosensing - Chen, Min, Khalid, Syma, Sansom, Mark S.P. and Bayley, Hagan Published:2008Publication:Proceedings of the National Academy of Sciences of the United States of AmericaVolume:105, (17)Page Range:6272-6277doi:10.1073/pnas.0711561105 Coarse-grained MD simulations of membrane protein-bilayer self-assembly - Scott, Kathryn A., Bond, Peter J., Ivetac, Anthony, Chetwynd, Alan P., Khalid, Syma and Sansom, Mark S.P. Published:2008Publication:StructureVolume:16, (4)Page Range:621-630doi:10.1016/j.str.2008.01.014

近期论文